ALL-CAP TEXT REDUCES READING SPEED BY ABOUT TEN PERCENT. MIXED-CASE LETTERS HAVE VARIATIONS THAT BREAK UP THE TEXT INTO RECOGNIZABLE SHAPES, WHEREAS A PARAGRAPH IN ALL CAPS HAS UNIFORM HEIGHT AND SHAPE, MAKE IT APPEAR BLOCKY AND RUN TOGETHER. ALSO, THE USE OF ALL CAPS CAN SEEM CHILDISH AND AMATEUR, OR AGGRESSIVE OR UNPROFESSIONAL. RESERVE ALL-CAP TEXT FOR SHORT HEADINGS AND TITLES, AND FOR SHOUTING.
Prioritizing Web Usability by Jakob Nielsen, Hoa Loranger.